Environment Canada issued a Monday winter travel advisory.
According to the agency, anywhere from 5-10 cm of snow could fall in the region, leading to poor visibility and slick roads.
The advisory covers London-Middlesex and Elgin as well as Oxford-Brant, Elgin, Oxford, Sarnia, Lambton, Norfolk, and Elgin.
Huron, Perth and Grey-Bruce have snow squall alerts.
The snow is expected not to melt after midnight.
Motorists should always be aware of the conditions.