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![Histone markers enrichment across different platforms and loci. A Venn diagrams showing comparison between Illumina and microarray data for H4ac-associated genes. Comparison of H4ac-associated loci identified in three conditions of interest on different platforms: Illumina HiSeq replicates of ChIP-Seq data, and comparison of this data on the transcriptome level with microarray analysis. For Illumina, genes were considered to be significant in that condition if the peak summit generated by MACS was situated within identified loci. In the microarray data, genes with at least a 2-fold difference in their expression levels were evaluated with Student’s t test, and genes with p-values < 0.05 were counted as differentially expressed in the condition of interest. Diagrams created in BioVenn [73]. B Up- and downregulated genes identified by microarray analysis in three conditions of interest compared to the untreated WT control. C Histone marker enrichment distribution 2.0 kb upstream of transcription start sites (TSSs) and downstream of transcription termination sites (TTSs). The log2 ratio of ChIP signal to input on aligned files was calculated for both H4ac (upper panel) and H3K27me3 (lower panel) histone modifications using bamCompare from the deepTools2 package (Galaxy version 3.0.2.0) [74, 75] on WT and axe1-5-untreated and MeJA-treated samples. One representative replicate is shown. Credit: <i>BMC Biology</i> (2022). DOI: 10.1186/s12915-022-01273-8 Unwinding the secrets of stress in plants could help feed the world during climate crisis](https://scx1.b-cdn.net/csz/news/800a/2022/unwinding-the-secrets.jpg)
Royal Holloway’s new research has shown that plants’ natural responses to stress alter the DNA structure of cells to help them withstand the adverse effects of climate change on their growth.
The new research published in BMC BiologyProfessor Alessandra devoto, Department of Biological Sciences at Royal Holloway and her team, in collaboration Dr. Motoaki Seki from RIKEN Centre for Sustainable Resource Science in Yokohama, Japan and Doctor Jong-Myong Kim from Ac-Planta Inc, used the model plant Arabidopsis thaliana, (Thale cress), to stress the plant’s internal mechanisms.
This allowed the team to study how stress can affect the way DNA is coiled within cells to switch on and off genes. Understanding these mechanisms could help plants survive in adverse environments like drought. This would make them more resilient to climate change.
Professor Alessandra Devoto of the Department of Biological Science at Royal Holloway stated: “Our research has demonstrated that changes in the natural modification of the proteins binding to the plant DNA (namely ‘Modifications to histoneThese traits, such as acetylation (or methylation), could be passed on to future generations to increase plant resistance to cold and pathogen attacks.
“This is very important data considering the Climate changeCrisis, as it becomes increasingly difficult to grow crops for the world’s food needs.
Stacey Vincent, Ph.D. Student from Royal Holloway, said: “Being capable of creating plants that can resist adverse environments will be a real game-changer.” We are thrilled to have discovered these highly-tuned stress responses within plants.
Dr. Jong Myong Kim from Ac-Planta Inc. and the University of Tokyo said: “This research shows how stress has repercussions throughout the whole plant genome, and it is universally preserved between plants and animals.”
Dr. Seki from RIKEN Centre for Sustainable Resource Science in Yokohama stated: “These findings represent an important milestone towards understanding the mechanisms through which PlantsThese are essential to guarantee your security Animal lifeCan the planet become more resilient to future challenges?
“We are proud to be able lend a helping hand for plant life.
Stacey A. Vincent, Jasmonates, and Histone Deacetylase 6 activate Arabidopsis genomic-wide histone activation and methylation during early acute stress response. BMC Biology (2022). DOI: 10.1186/s12915-022-01273-8
Citation:
The world could be fed during the climate crisis (2022, April 11,) if we can unravel the secrets of stress in our plants.
Retrieved 11 April 2022
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